Fri Jan 16 2026

99 articles - From Friday Jan 09 2026 to Friday Jan 16 2026

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol
AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review.

These Best Practice Advice statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these Best Practice Advice statements do not carry formal ratings of the quality of evidence or strength of the presented considerations.

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AGA Clinical Practice Update on the Role of Therapeutic Endoscopy in Inflammatory Bowel Disease: Commentary.

Methods This CPU was commissioned and approved by the AGA Institute CPU committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPU committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. This communication incorporates important and recently published studies in the field, reflecting the experiences of the authors.

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Gastrointest Endosc
ASGE consensus recommendations on the endoscopic management of eosinophilic esophagitis - part 2: disease assessment, monitoring, and pediatric considerations.

Statements across al age ranges addressed the role of less-invasive monitoring, performing diagnostic endoscopy off treatment, the need to consider symptoms, endoscopic features, and histologic findings when assessing disease activity, treatment-based monitoring intervals, and the approach to esophageal biopsies during monitoring. Coupled with the original consensus work, we provide a comprehensive endoscopic approach to EoE as well as practical guidance for procedure-related aspects in the field to facilitate high-quality endoscopic care to patients with EoE.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther
Statin Therapy Independently Reduces Mortality and Liver Complications in Patients With Cirrhosis: An Updated Systematic Review and Meta-Analysis.

Statin therapy is associated with improved survival in cirrhosis, supported mechanistically by reductions in portal pressure. Observational evidence suggests benefits for decompensation and HCC, though these remain uncertain due to residual confounding. Large-scale, long-term RCTs are needed to clarify the role of statins as disease-modifying therapy in cirrhosis.

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Am J Gastroenterol
Imaging Based Modalities for Identifying "At Risk" MASH. A Diagnostic Test Meta-analysis.

FAST with its accessibility and robust diagnostic performance may be well-suited for large-scale application. MRI-based techniques are effective non-invasive options for diagnosing "at risk" MASH in MASLD and may provide strong alternatives. Rather than challenging existing perspectives, this study provides a reflective overview of current evidence on imaging-based modalities for "at risk" MASH.

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The Impact of Body Weight Change on Liver Histology in Metabolic Dysfunction-Associated Steatotic Liver Disease Across Various Histological Endpoints: A Systematic Review and Meta-Analysis.

Even modest observed weight loss is associated with MASH resolution. MASH resolution and ≥1-stage fibrosis improvement are not impacted by BMI, T2DM or Hispanic/Latino ethnicity, reinforcing the importance of lifestyle interventions across populations. The proportions observed serve as benchmark estimates of histological response for future clinical trial design.

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Clin Gastroenterol Hepatol
Impact of 20% Change in VCTE-measured Liver Stiffness on Liver-related Outcomes: A systematic Review and Meta-Analysis.

These findings highlight the potential of serial LSM measurements for monitoring chronic liver disease and for clinical trial endpoints. Prospective longitudinal studies are needed to evaluate if changes in LSM measurements over time are linked to improved patient outcomes.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Characterisation and Prognostic Implication of Cholestasis After Burn Injury.

Cholestasis is frequent following burn injury. Prognosis is determined by bilirubin dynamics independently of disease and burn severity. Hyperbilirubinemia is associated with excess mortality ≥ 7 days after surviving burn injury.

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Clinical Trial: Semaglutide Versus Placebo in NIT-Assessed MASH-A Multicenter Randomised Placebo-Controlled Trial (SAMARA).

A NIT-based approach to identify at-risk MASH patients for semaglutide treatment is feasible and effective. This study provides RCT data showing that FAST, ALT, AST and MRI-PDFF can be used to monitor treatment response.

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PNPLA3 Genotype and Clinical Factors Impact Hepatocellular Carcinoma Risk: Findings From a Prospective Cohort Study.

The frequency of rs738409-G alleles was associated with a dose-dependent increase in HCC risk and was independent of other clinical risk factors. Among participants who were male, overweight, and those with diabetes, the risk of HCC was further elevated among those with rs738409-G alleles. These data may be helpful for the development of future risk stratification strategies.

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Tumour Burden Score as a Predictor of Extrahepatic Progression After Transarterial Chemoembolization for Hepatocellular Carcinoma: An Observational Multicenter Study.

Extrahepatic dissemination is infrequent in HCC patients treated with TACE. TBS is easily calculable and helps in identifying patients at higher risk of metastasis development.

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Am J Gastroenterol
A Large Language Model Assistant for Summarizing Hepatology Referral Documents.

The use of an LLM led to significantly reduced document length, maintained an appropriate level of accuracy, and led to a significant decrease in clinician time to review the patient record. Future steps involve creating a fully automated workflow that is integrated into the electronic health record for widespread use.

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Adenomatous Polyposis Coli Gene Polyposis-related Syndromes.

In this narrative review, we discuss the epidemiology, diagnosis, and management of APC gene related polyposis syndromes. We also review the variation in genotype-phenotype presentations and discuss practical aspects of caring for individuals affected by these syndromes with an emphasis on multidisciplinary care, family planning, and transitions of care.

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Association Between Antibiotic Use for Non-Gastrointestinal Infections and Inflammatory Bowel Diseases Flare-Ups: A Self-Controlled Case Series Study.

Antibiotic use for non-GI infections was associated with a short-term increase in IBD flare risk. Injectable or narrow-spectrum antibiotics may have a relatively smaller impact on potential IBD flare-ups.

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Associations Between Mean Arterial Pressure Thresholds and Clinical Outcomes in Decompensated Cirrhosis With Septic Shock.

Maintaining MAP between 70 and 75 mm Hg may optimize survival and kidney recovery in patients with decompensated cirrhosis and septic shock. Randomized trials are needed to compare traditional MAP targets (60-65 mm Hg) with intermediate targets (70-75 mm Hg) to improve outcomes in this high-risk population.

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Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.

Based on our evaluation, future trials should use co-primary clinical and radiologic assessments to capture both how the patient feels and an objective measure of disease activity. These findings reinforce the need for clearly defined, objective, and standardized endpoints for pCD clinical trials that will enable evaluation of novel therapies to improve patient outcomes.

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Comparative Outcomes of Flexible Endoscopy, Rigid Endoscopy, and Open Surgery for Zenker's Diverticulum Repair: A Retrospective Matched Cohort Study.

In this matched cohort, FE has clinical success comparable to OS and superior to RE for ZD repair, with shorter hospital stays, reduced procedure lengths, and a trend toward fewer adverse events. Our matched, multi-center design provides stronger comparative evidence than prior unmatched studies. These findings support FE as a first-line treatment for ZD repair, though prospective studies could further clarify long-term outcomes.

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Postimaging Colorectal Cancer After Computed Tomography Colonography: A Danish Nationwide Study.

We found a higher overall PICRC-3y-rate than previously reported. The overall PICRC-3y-rate was also higher than reported 3-year rates for postcolonoscopy CRCs.

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Resection depth of underwater versus conventional endoscopic mucosal resection for intermediate-sized colorectal tumors.

UEMR achieved a resection depth comparable to that of CEMR. Given its consistent negative horizontal margins, UEMR may become the gold standard for resecting intermediate-sized colorectal tumors.

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The Enterolimbic axis: gut-brain affective circuits at the crossroad of metabolism, emotion, and behavior.

We propose that gastroenterologists embrace these agents as first-line therapies, leveraging the unique endocrine role of the gut in metabolic regulation. This review integrates molecular, clinical, and therapeutic insights to outline diagnostic and precision-medicine opportunities arising from enterolimbic modulation.

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The Time-Dependent Association Between Irritable Bowel Syndrome and All-Cause and Cause-Specific Mortality in the NIH-AARP Cohort Study.

We found time-dependent inverse associations between IBS and all-cause, cancer and cardiovascular disease mortality. Although this association seemed to be strongly confounded by personal health advocacy/healthcare access during very short follow-up, further research is needed to explore the factors contributing to these associations observed after longer follow-up.

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The Utility of MUC2 and CDX2 Expression in the Diagnosis of Barrett's Esophagus: A Community-based Study of Wide-Area Transepithelial Sampling and Forceps Biopsies.

MUC2 immunohistochemistry may be more sensitive and specific for diagnosing BE than goblet cells by FB. FB misses approximately half of BE when using MUC2/WATS3D as an alternative gold standard. The addition of MUC2 immunohistochemistry may aid in the recognition of BE.

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Clin Gastroenterol Hepatol
Serum IgG Response to a Conserved Domain of Commensal Flagellins Predicts Future Risk of Crohn's Disease in First-Degree Relatives.

Increased antibody response in healthy FDRs towards Lachnospiraceae flagellins is associated with future risk of CD. Importantly, pre-CD subjects shared seroreactivity towards a conserved bacterial flagellin epitope, which may represent an early pre-clinical biomarker of CD.

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Endoscopy
Approaches to assessing completeness of polyp resections in clinical practice: a systematic scoping review.

Different methods are available to assist in visual confirmation of complete resection and measuring IRRs, with considerable variability in their application. This review highlights the need for standardized assessment of complete colorectal polyp resection.

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Universal submucosal dissection outperforms selective mucosal resection in early esophageal adenocarcinoma.

ESD achieved higher complete resection rates for both T1a and T1b cancers without increased morbidity. ESD may therefore represent the preferred strategy for early EAC, potentially reducing unnecessary surgery.

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Gastroenterology
Endoscopic Ultrasound-Guided Choledochoduodenostomy vs Endoscopic Retrograde Cholangiopancreatography in Malignant Distal Biliary Obstruction to Prevent Postprocedural Pancreatitis: A Randomized Trial.

EUS-CDS is superior to ERCP in reducing postprocedural acute pancreatitis risk. However, the overall risk of AEs was not significantly different and warrants further investigation. Additionally EUS-CDS showed improved technical success and comparable clinical efficacy. These results support a potential role of EUS-CDS as primary approach in selected patients with dilated common bile duct (ClinicalTrials.gov, Number NCT04099862).

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Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.

Our results indicate that BRAF-mutated serrated polyps are molecularly more similar to normal colon tissue than APC- and/or CTNNB1-mutated tumors. Overall, molecular tumor profiling of individuals with polyposis contributes to understanding the genetic disease etiology.

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Gut
Complement-secreting CAFs are associated with better prognosis in pancreatic cancer: single-cell multiomics.

Patients with a higher composition of csCAFs have significantly longer overall survival and recurrence-free survival through multiplex immunohistochemistry and bulk RNA-seq deconvolution. Our study demonstrates that csCAFs may represent an early-stage iCAF subtype and suggests a promising strategy for reprogramming iCAFs into csCAFs.

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KRAS mutation-driven O-GlcNAcylation of CLDN18.2 enhances the progression of pancreatic cancer and reduces the efficacy of CLDN18.2-targeted therapy.

KRAS mutations and hyperglycaemia drive O-GlcNAcylation of CLDN18.2 at its C-terminal T204 site. O-GlcNAcylated CLDN18.2 promotes poor prognosis and reduces the effectiveness of CLDN18.2-targeted therapies. Low dose MRTX1133 restores CLDN18.2 membrane localisation by reducing its O-GlcNAcylation and augments CLDN18.2-targeted therapy efficacy, offering a novel combinatorial strategy for KRAS-mutant PDAC.

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Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure.

Manipulation of zinc availability altered ZFP36L1 activity and expression of its direct targets. These findings uncover a zinc-dependent ZFP36L1-regulon that governs hepatocyte fate by repressing p21- and JAG1-driven senescence and NOTCH activation and highlight ZFP36L1 as a promising therapeutic target in ALD.

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Hepatology
Anatomic subsets of cholangiocarcinoma: More different than alike.

Emerging strategies for early diagnosis and chemoprevention in high-risk populations further emphasize the significance of recognizing the unique biology of each subtype. In this review, we provide a comprehensive overview of the distinct anatomic subsets of CCA, integrating their molecular and biological foundations with clinical management to inform practice and guide future research.

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Biologically explicable multimodal model predicting local tumor progression and tumor invasiveness of hepatocellular carcinoma.

The 8 mm MAM ablation strategy can effectively decrease the LTP incidence of high-invasiveness group (from 42.4% to 10.5%, p=0.027) to the level comparable to low-invasiveness group (10.5% vs 6.1%, p=0.613) in external test set. Multimodal model achieved satisfactory performance on classifying tumor invasiveness, and provided effective strategy for high-invasiveness tumor to reduce LTP occurrence.

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Biologically interpretable deep learning-derived MRI phenotypes reveal lymph node involvement and neoadjuvant therapy response in intrahepatic cholangiocarcinoma.

The SwinU-CliRad model can serve as a biologically interpretable tool for LN risk stratification in iCCA surgical candidates, with high-risk patients identified by the model potentially deriving benefit from NAT.

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Clinical utilization of testing for cell-free DNA in hepatocellular cancer.

In contrast, the use of cfDNA for risk stratification, prognostication, and minimal residual disease detection remains in the early stages of clinical development. Future multicenter studies with standardized methodologies and rigorous validation will be essential to translate cfDNA into routine clinical practice for the management of HCC.

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Liverrisk score (LRS) predicts long-term liver-related outcomes in a cohort of veterans without evidence of liver disease.

LRS effectively predicted liver-related events, mortality, and HCC in Veterans. Its integration into clinical alerts and lab reports could support proactive patient care and liver disease prevention.

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NRF2-COX2-PGE2 axis drives immune cold tumors and predicts resistance to combination immunotherapy in hepatocellular carcinoma.

Tumor-intrinsic activation of the NRF2-COX2-PGE₂ axis drives immune cold TMEs and mediates Atez/Bev resistance in HCC. Targeting this pathway may enhance efficacy, and plasma PGE₂ represents a non-invasive biomarker for stratification.

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Repurposing resmetirom suppresses MASH-associated hepatocellular carcinoma, with mechanistic implications of MDK/LRP1-mediated metabolic reprogramming and immunosuppression.

Targeting the MDK/LRP1 axis with Resmetirom offers a promising therapeutic strategy for MASH-associated HCC, addressing both metabolic dysfunction and tumor progression.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial: Post Banding Ulcer Bleeding-Is There Scope for Prevention?

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Gastroenterology
In Memoriam: Pelayo Jesus Correa, MD (1927-2025).

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J Hepatol
Standing on the shoulders of giants.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
A Rare Cause of Ascites.

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An Unusual Complication Postgastrectomy: A Large Stone Formed on Retained Sutures at the Periampullary Region.

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Autoimmune Hepatitis and Depression.

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How I Approach It: A Roadmap for AI in GI Fellowship Training.

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Inverted Hyperplastic Polyp of the Duodenum.

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Letter to the Editor.

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Letter to the Editor.

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Leveraging malleability: lithotripsy basket retrieval of an impacted esophageal medication blister foil pack.

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Primary hepatic somatostatinoma (G2) with diabetes and nodal metastasis: An exceptionally rare primary liver tumor.

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Something fishy in the liver - an unexpected mass in a patient with heavy alcohol use.

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The appendix as a diagnostic blind spot: a case of concealed tubular adenoma.

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Clin Gastroenterol Hepatol
Animal Naming Test Predicts Future Overt Hepatic Encephalopathy.

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Endoscopy
"Umbrella-shaped pulley traction" assisted endoscopic submucosal dissection of colonic lesions - a modified external traction technique.

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A fishy situation - expanding the differential diagnosis of the fish-mouth papilla.

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A helix tacking system for the management of colonic anastomotic dehiscence, after a laparoscopic left colectomy.

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A novel approach: a pancreatic duct stent removable with the nasobiliary catheter.

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A novel robotic traction system for endoscopic submucosal dissection - achieving en bloc resection of an extensive laterally spreading tumor in the lower rectum.

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A rare case of hepatic hilar lymphangioma diagnosed using endoscopic and transabdominal ultrasonography.

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Cholangioscopy and double guidewires facilitate a difficult endoscopic ultrasound-guided gastroenterostomy.

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Combined digestive endoscopy and laryngoscopy for successful management of an early-stage epiglottic carcinoma.

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Endoscopic management of a giant ampullary cyst causing acute pancreatitis.

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Endoscopic replacement of a transgastric feeding tube in advanced oropharyngeal cancer with esophageal obstruction using transgastrostomy endoscopy.

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Endoscopic resection in early Barrett's esophagus-associated adenocarcinoma: does a universal endoscopic submucosal dissection approach make the cut?

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Endoscopic stricturoplasty for pyloric stenosis refractory to endoscopic balloon dilation and lumen apposing metal stenting.

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Endoscopic synchronous injection and submucosal dissection for large granular mixed nodular laterally spreading tumor in the rectum.

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Endoscopic ultrasound-guided antegrade transpapillary multi-hole self-expandable metal stent with fine-gauge stent delivery system.

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Endoscopic ultrasound-guided choledochoduodenostomy as a life-saving salvage therapy for post-transplant acute biliary obstruction.

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Endoscopic ultrasound-guided portal pressure gradient assessment of acute hemodynamic response to intravenous propranolol.

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Endoscopic ultrasound-guided radiofrequency ablation followed by ethanol ablation of a solid pseudopapillary neoplasm of the pancreas.

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Hemostasis via an endoscopic full-thickness suturing device with extended cap length method and red dichromatic imaging for deep colonic diverticular bleeding.

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High-fidelity endoscopic submucosal dissection simulator reproducing full-procedure training, bleeding, and perforation.

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Knocking stent release technique to deploy lumen-apposing metal stents during endoscopic ultrasound-guided gallbladder drainage.

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Rescue surgery for intra-abdominal migration of plastic stents in endoscopic ultrasound-guided hepaticogastrostomy.

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Side-by-side 6-mm multi-hole metal stents more effective than inside plastic stents for reintervention after stent-in-stent placement in malignant hilar biliary obstruction.

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Simple water infusion via a non-traumatic tube facilitates endoscopic resection of an appendiceal-orifice polyp.

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Stent-in-stent placement of multi-hole metal stents (M2) for malignant hilar obstruction allows re-intervention as easily as with plastic stents.

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Successful endoscopic submucosal dissection of a large laterally spreading tumor in distal jejunum by the water pressure method using a newly developed double-balloon enteroscope.

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Tetra-side-by-side technique using a multi-hole self-expandable metal stent with a 5.9-Fr stent delivery system.

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Transcolonic endoscopic appendectomy using a novel integrated snare-knife device: a case report.

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Underwater internal traction-assisted reopenable clip-over-the-line method for full-thickness defect closure in a gastric collapse.

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Gastroenterology
An Unusual Cause of Mucopurulent Bloody Stool and Blurred Vision.

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Life-Threatening Hematemesis and Esophageal Stricture in a 9-Year-Old Boy: Unmasking the Culprit.

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Hepatology
Fellows' Corner.

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From intuition to index: Combining frailty and comorbidities to stratify liver transplant risk.

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Fueling fibrosis: The PBX1-IL7R axis and its role in hepatic stellate cell activation.

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Hepatocellular carcinoma with macrovascular invasion : Navigating heterogeneous evidence.

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Letter to the Editor: Placebo drift, dose heterogeneity and the winner's curse - re-evaluating the hierarchy of MASH therapeutics.

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Letter to the Editor: The PNPLA3 paradox: Does genotype modify the clinical utility of the MASLD framework in children.

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MASLD: To screen or not to screen-That is the question.

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Metabolic syndrome and cholangiocarcinoma: A signal too strong to ignore.

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Population-level screening for liver disease: Opportunities and challenges.

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Reply: Placebo drift, dose heterogeneity and the winner's curse - re-evaluating the hierarchy of MASH therapeutics.

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Reply: The PNPLA3 paradox: Does genotype modify the clinical utility of the MASLD framework in children?

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J Hepatol
Enhancing intestinal goblet cell-associated antigen passages could attenuate ALD.

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Redox-dependent substrate use in hepatic gluconeogenesis shapes exercise performance.

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Letters&Replies

Letters to the editors and authors’ replies

Gut
Should the China-CLIF framework influence model for end-stage liver disease-based transplant priority in acute-on-chronic liver failure?

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J Hepatol
Bridging Disciplines in Portopulmonary Hypertension: A Multidisciplinary Call for Harmonized Patient Management.

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Emergency granulopoiesis in decompensated cirrhosis: mechanistic and therapeutic considerations.

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Hypertension and Long-Term Adverse Clinical Outcomes in MASLD: Sensitivity Analyses for Unmeasured or Uncontrolled Confounding.

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